A single center experience in resectable pancreatic ductal adenocarcinoma : the limitations of the surgery-first approach. Critical review of the literature and proposals for practice update
| Journal | Volume 80 - 2017 |
| Issue | Fasc.4 - Original articles |
| Author(s) | R. Dumont, F. Puleo, J. Collignon, N. Meurisse, M. Chavez, L. Seidel, P. Gast, M. Polus, C. Loly, Ph. Delvenne, P. Meunier, R. Hustinx, A. Deroover, O. Detry, E. Louis, Ph. Martinive, D. Van Daele |
| Full article | This article has been withdrawn by the authors because of incorrect authorship, which is considered a form of unethical publication. The editorial board gave its approval to retract the manuscript. |
| (1) Gastroenterology and Medical Oncology, Digestive Oncology Clinic, CHU Sart Tilman, Liège, Belgium ; (2) Digestive Oncology, Jules Bordet Institute, ULB, Brussels, Belgium ; (3) Digestive Surgery, CHU Sart Tilman, Liège, Belgium ; (4) Clinical Hematology, CHU Sart Tilman, Liège, Belgium ; (5) Biostatistics, SIME, CHU Sart Tilman, Liège, Belgium ; (6) Anatomopathology, CHU Sart Tilman, Liège, Belgium ; (7) Medical Imaging, CHU Sart Tilman, Liège, Belgium ; (8) Radiotherapy, CHU Sart Tilman, Liège, Belgium. |
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Background and study aims : The current standard of care for resectable pancreatic ductal adenocarcinoma (PDAC) is surgery- first followed by adjuvant chemotherapy. We review our single center experience in a PDAC cohort managed by the surgery- first strategy. We then compare our data to those of Belgian and international literature. Patients and methods : We reviewed a series of 83 consecutive resectable patients with PDAC, treated by the surgery- first approach in a Belgian Academic Hospital between 2007 and 2013. The outcomes were assessed with univariate and multivariate Cox regression analysis. Kaplan-Meier curves were drawn according to patient groups. Results : For the entire population, the median survival (MS) was 18.4 months; the 1-year relapse-free survival was 56%, and the 5-year overall survival (OS) was 13%. The size of the primary tumor larger than 3 cm (OS, HR = 1.76, p = 0.033) and vascular resection (DFS, HR = 2.1, p = 0.024) were the single independent prognostic factors in the multivariate analysis of this cohort. |
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© Acta Gastro-Enterologica Belgica. PMID 29560639 |
